Dealing with medication for mononucleosis can be challenging enough, but when you add relapsing remitting multiple sclerosis (RRMS) into the mix, it can get even more complicated. Mononucleosis, often caused by the Epstein-Barr virus, can be particularly hard on those with autoimmune conditions like MS. Many people diagnosed with mononucleosis experience extreme fatigue, sore throat, and swollen glands. However, the fatigue from mononucleosis can sometimes be mistaken for MS-related fatigue, leading to delays in diagnosis or treatment. When it comes to medication, the options for treating mononucleosis are mostly supportive rather than curative. Rest, hydration, and over-the-counter pain relievers are often recommended. But what if you have RRMS and you're on medications like Solumedrol or tapered prednisone? These medications can suppress the immune system, potentially worsening viral infections like mononucleosis. Additionally, certain medications for mononucleosis might interact with MS treatments, leading to complications. Has anyone here had to deal with mononucleosis while managing their MS? What medications did you use, and how did it affect your MS symptoms? Sharing our experiences can provide valuable insights for those facing this dual challenge.